No ....AMD64 is the best way for many reasons...AMD graphics card whith pci express will be also supported (os4 support partially such cards)
I prefer also ISA like arm or mips or powerpc e6500 but i fact there is no desktop machine mass producted with those ISA... and the power stay behind AMD64. Arm cortex A15 is a lot faster than Intel Atom; but versus a core I3 or any AMD FX it's not the same.
Processor power is a need for descent browsing speed,for html5 games like angry birds for exemple....

Amd64 ISA offert more power for lower prices.....it's not a joke...it's real.
Powerpc is dead for desktop, Mips is only for super computers, no mainstream manufacturer use it. And Arm is growing fast, it's interesting but only chromebook use it for now.

[ Edited by acepeg 28.08.2015 - 22:35 ]