I'm new to MorphOS with 2.5 on a Mac Mini. I am able to
launch Amiga apps via Trance. What if I have a game that's on an ADF image? What's the process for playing this game? What if my game has multiple disks? I've searched around on the web but can't find a howto of any sort. If someone could point me in the right direction I'd be much obliged.

One thing I'll mention. I downloaded some zipped game from
aminet and when I launched in MorphOS the monitor went to 320 x 200 or something and froze. That's why I'm asking, not sure how it all works.

For many 68k games you need E-UAE amiga emulator.

Here is one excellent tutorial how to setup E-Uae on MorphOs. http://obligement.free.fr/articles/euae.php

there is this tutorial too:

http://obligement.free.fr/articles/integrer_euae_ambient.php