In 2525 we won't have MorphOs
- All the Amiga die hards have died by then
- Current trend on dumbing down computers and software has continued and a WIMP will be something like dinosaurs
- Humans have probably caused a major disaster that might or might not have resulted in our species death

Besided that, I think MorphOs simply needs more developers and a few kick ass applications and we'll be settled for a few more decades.