Amiga flavours can't run apps with different endianness in the same memory space and most of amiga apps are compiled big endian and there's no possibility of recompiling. You could recompile a few apps to use little endian but you would probably lose compatibility with 680x0 and PPC so keep in mind your sweet dreams may turn into something quite insipid. No bigendian cpu means no 680x0 apps.
I don't know why some people is so naive thinking that amiga like OSes would be successful on x86 just because it runs on x86. Most of people couldn't stand lack of memory protection, multiuser and lack of java, apps... who cares about Joe User? I don't. I enjoy my hobby and that's all. Running on x86 would bring incompatibility but wouldn't bring memory protection or apps.
