For those trying D3 with new MOS 3.18 and have issues with mouse/menu/gfx the fix is not really there:

As I suspected from and old debug beta done from someone with a beta 3.18 SDK, game recompiled with new SDK works now for supposedly all machines that were problematic.

And I don't really know why the f new SDK fixes that :)

Anyway working on for another release.

PS: Does game now looks better with shader render with new MOS upgrade ???